Neurology
Antiepileptic Drug Comparison: More Details Print E-mail
Written by Myette   
A post hoc analysis of the focal epilepsy arm in the SANAD trial reveals outcome predictors for patients receiving specific AED treatments.

In the Standard and New Antiepileptic Drug (SANAD) trial (JW Gen Med Apr 10 2007), 1721 patients with suspected focal epilepsy were randomized equally to carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate, to compare outcomes with the newer medications versus the older medication (carbamazepine). Now, researchers have conducted a post hoc analysis of the data to determine clinical factors that affect the probabilities of treatment failure and of achieving 12-month remission. Time to treatment failure was divided into failure caused by inadequate seizure control or by unacceptable adverse effects.
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The Effect of Aspirin in Essential Thrombocythemia Print E-mail
Written by Myette   
Aspirin has shorter-lasting effects in patients with ET than in those with normal platelet turnover.

Aspirin is recommended for the prevention and treatment of thrombosis in patients with essential thrombocythemia (ET). However, incomplete suppression of platelet activation by aspirin appears to be common in patients with ET, possibly because the rapidly proliferating megakaryocytes escape from the effects of aspirin given only once every 24 hours. Platelets produced by these megakaryocytes might retain functionality.
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Antipsychotics and Myocardial Infarction... Print E-mail
Written by Myette   
Antipsychotics and Myocardial Infarction in Dementia Patients

The risk for MI was significantly elevated in the first month after initiation of antipsychotics in dementia patients already treated with cholinesterase inhibitors.
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Motor Restlessness in Parkinson Disease Print E-mail
Written by Myette   
A comparison of unmedicated patients with Parkinson disease and controls showed a nearly three times increased prevalence of leg motor restlessness but not typical restless legs syndrome.

Sleep disorders are common in patients with Parkinson disease (PD). Restless legs syndrome (RLS) is a prevalent sensorimotor disorder in the general population. The prevalence of RLS in the PD population has varied widely in studies, likely related to various diagnostic criteria and variations in use of dopaminergic agents that can treat both conditions.
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The Benefits of Early Epilepsy Surgery Print E-mail
Written by Myette   
Early surgical treatment was better than medical therapy alone for refractory mesial temporal lobe epilepsy in an aborted clinical trial that leaves questions about important secondary outcomes..
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