Articles : HIV/AIDS
  • Telaprevir for Genotype 1 Hepatitis C...

    Added On : 8th June 2013

    Telaprevir for Genotype 1 Hepatitis C in HIV-Coinfected Patients

    In a small phase II study of telaprevir versus placebo in combination with standard HCV therapy, SVR rates were higher among telaprevir recipients, with no detrimental effects on HIV control.

  • Functional Impairment in HIV-Infected Patients

    Added On : 26th May 2013

    In patients on suppressive antiretroviral therapy, greater CD8-cell activation and higher interleukin-6 level are associated with functional impairment.

    In aging HIV-uninfected individuals, immune activation and inflammatory markers are associated with declines in physical function and increased frailty. Given evidence that, despite years of suppressive antiretroviral therapy (ART), HIV-infected patients have higher levels of T-cell activation and inflammation than HIV-uninfected individuals, investigators examined whether these markers are associated with functional impairment in HIV-infected patients.

  • HIV-Mediated CD8 Encephalitis...

    Added On : 12th May 2013

    HIV-Mediated CD8 Encephalitis: Adding Fuel to the Immune-Dysregulation Fire

    Clinicians describe a CNS inflammatory complication in HIV-infected patients on long-term antiretroviral therapy whose outcomes ranged from death to total recovery with adjunctive glucocorticoids.

  • HCV Testing in HIV-Infected MSM...

    Added On : 29th April 2013

    HCV Testing in HIV-Infected MSM: Once Is Not Enough

    A high incidence of HCV seroconversion in this population implies that repeat HCV testing should be routinely performed, particularly in individuals with high-risk sexual behaviors.

  • Higher Tenofovir Trough Concentrations...

    Added On : 16th April 2013

    Higher Tenofovir Trough Concentrations and Renal Dysfunction

    High trough levels of tenofovir, seen in half the patients taking the drug, were associated with renal impairment.

  • No Major Breakthroughs in Biomedical Prevention

    Added On : 3rd April 2013

    Results presented at CROI 2013 underscore some of the barriers to pre-exposure prophylaxis.

    Studies presented at CROI 2013 remind us that, as prevention goes biological, human behavior still determines outcomes.

  • 2-Week vs. 4-Week Rotations...

    Added On : 21st March 2013

    2-Week vs. 4-Week Rotations for Inpatient Teaching Physicians: A Randomized Trial

    Length of stay and readmissions were unaffected, but attending physician burnout was more likely with 4-week rotations.

  • A Firmer Link Between HIV and Cardiovascular Disease

    Added On : 20th March 2013

    A huge, well-controlled study affirms that HIV infection, whether treated or not, is an independent cardiovascular risk factor.

    Despite much study, the connection between HIV and coronary heart disease (CHD) remains tantalizingly difficult to confirm, in part because few studies have been able to definitively control for all the more traditional cardiovascular risk factors. Now, researchers have followed up a large prospective cohort of more than 82,000 veterans (mean age, 48; 97% men; 48% black) from 2003 through 2009 for development of myocardial infarction (MI). About one third of participants were HIV infected, and at baseline about half of these individuals were receiving antiretroviral therapy (ART).

  • Hepatitis Flares and Mortality in Patients...

    Added On : 6th March 2013

    Hepatitis Flares and Mortality in Patients with HIV and Hepatitis Virus Coinfection

    Pretreatment inflammation and coagulation biomarkers are associated with increased risk for these important complications after initiation of antiretroviral therapy.