• An Encouraging Trial of a Mesh-Covered Stent...

    Added On : 23rd December 2012

    An Encouraging Trial of a Mesh-Covered Stent in Primary Percutaneous Coronary Intervention

    Compared with other devices, a bare-metal stent with a mesh covering to trap potentially embolic material was associated with a higher rate of ST-segment resolution.

  • A Hat Trick for a New Type of LDL-Lowering Agent

    Added On : 6th January 2013

    In three separate phase II trials, a proprotein convertase subtilisin/kexin type 9 protease inhibitor achieves significant reductions in LDL levels compared with placebo or ezetimibe.

    Statin therapy, which reduces both low-density lipoprotein cholesterol (LDL-C) levels and cardiovascular risk, is unsuccessful in many patients because of poor response, intolerance, allergy, or a combination of the three. Nonstatin agents also lower LDL-C levels; to date, however, few data support their effectiveness at improving clinical outcomes. Attention is now focused on investigational, fully human, monoclonal antibodies directed against proprotein convertase subtilisin/kexin type 9 (PCSK9), which impairs the liver's ability to remove LDL-C from the blood. In three manufacturer-sponsored phase II studies of a subcutaneously administered PCSK9 inhibitor, AMG 145, investigators assessed the potential of this approach in different patient cohorts with or at risk for cardiovascular disease.

  • Heart Failure with Breast Cancer Chemotherapy...

    Added On : 19th January 2013

    Heart Failure with Breast Cancer Chemotherapy: A Risk Worth Taking Seriously

    Findings from a large database suggest that trastuzumab is associated with higher rates of HF or cardiomyopathy in clinical practice than it was in clinical trials.

  • Rate Control for Atrial Fibrillation...

    Added On : 1st February 2013

    Rate Control for Atrial Fibrillation: What Is the Best Drug to Use?

    In a small, randomized crossover trial of four commonly prescribed beta- and calcium-channel blockers, diltiazem emerged the winner.

  • Incidence of Pulmonary and Venous Thromboembolism...

    Added On : 17th January 2013

    Incidence of Pulmonary and Venous Thromboembolism in Pregnancies After in vitro Fertilisation: Cross Sectional Study

    Peter Henriksson, professor, Eli Westerlund, physician, PhD student, Hċkan Wallén, associate professor, Lena Brandt, biostatistician, Outi Hovatta, professor, Anders Ekbom, professor

  • Effect of Not Monitoring Residual Gastric Volume...

    Added On : 17th January 2013

    Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding

    A Randomized Controlled Trial

    Jean Reignier, MD, PhD; Emmanuelle Mercier, MD; Amelie Le Gouge, MSc; Thierry Boulain, MD; Arnaud Desachy, MD; Frederic Bellec, MD; Marc Clavel, MD; Jean-Pierre Frat, MD; Gaetan Plantefeve, MD; Jean-Pierre Quenot, MD; Jean-Baptiste Lascarrou, MD; for the Clinical Research in Intensive Care and Sepsis (CRICS) Group

  • Failure to Renew Prescriptions for Gastroprotective Agents...

    Added On : 17th January 2013

    Failure to Renew Prescriptions for Gastroprotective Agents to Patients on Continuous Non-Steroidal Anti-Inflammatory Drugs Increases Rate of Upper Gastrointestinal Injury

    Le Ray I, Barkun AN, Vauzelle-Kervroëdan F, Bardou M

  • Dietary Sugars and Body Weight...

    Added On : 18th January 2013

    Dietary Sugars and Body Weight: Systematic Review and Meta-analyses of Randomised Controlled Trials and Cohort Studies

    Lisa Te Morenga, research fellow, Simonette Mallard, research assistant, Jim Mann, professor

  • Association of Prehospital Advanced Airway Management...

    Added On : 18th January 2013

    Association of Prehospital Advanced Airway Management With Neurologic Outcome and Survival in Patients With Out-of-Hospital Cardiac Arrest

    Kohei Hasegawa, MD, MPH; Atsushi Hiraide, MD, PhD; Yuchiao Chang, PhD; David F. M. Brown, MD

  • Adenovirus-Mediated Transcriptional Targeting...

    Added On : 18th January 2013

    Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells

    Rajendran S, O'Sullivan GC, O'Hanlon D, Tangney M