• Depression and AF in Women...

    Added On : 4th July 2012

    Depression and AF in Women: Don't Worry, Be Happy

    Psychological distress was not linked to atrial fibrillation in the Women's Health Study.

  • The Verdict Is In: Endoscopic Vein-Graft Harvest...

    Added On : 13th August 2012

    The Verdict Is In: Endoscopic Vein-Graft Harvest Is as Safe as Open Harvest

    A large contemporary, observational study allays concerns about long-term safety.

  • Can We Safely and Effectively Vaccinate Patients...

    Added On : 14th August 2012

    Can We Safely and Effectively Vaccinate Patients Receiving Biologic Therapies for Immune-Mediated Disease?

    Indications are promising but not definitive; nevertheless, we should discuss results with patients who request the herpes zoster vaccine.

  • HAS-BLED for Assessing Bleeding Risk...

    Added On : 27th August 2012

    HAS-BLED for Assessing Bleeding Risk with Anticoagulation: Best of the Mediocre

    Notwithstanding a lackluster performance, HAS-BLED beat two other scoring systems in a comparative analysis of trial data.

    Bleeding continues to be the Achilles heel of systemic anticoagulation, whether the agent used is warfarin or any of the new anticoagulants entering the market. Predictive models for bleeding include the following:

    HAS-BLED (hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly, drugs/alcohol)

  • Warfarin plus Aspirin After Aortic Valve...

    Added On : 9th September 2012

    Warfarin plus Aspirin After Aortic Valve Prosthesis Placement?

    An observational study suggests that the combination reduces mortality, at the cost of increased bleeding, when used in the 3 months after surgery.

    Patients receiving an aortic bioprosthesis have a low overall risk for thromboembolism, but controversy surrounds whether they benefit from anticoagulation in the first months after surgery. To address this issue, researchers used the Society of Thoracic Surgeons Adult Cardiac Surgery Database to compare the effectiveness of the early use of aspirin alone, aspirin plus warfarin, and warfarin alone.

  • Is Working Too Hard Really Bad for Your Heart?

    Added On : 23rd September 2012

    A collaborative meta-analysis suggests that the effect is real but smaller than previously thought.

    In a recent meta-analysis of published cohort studies, job strain was associated with about a 40% increase in risk for coronary heart disease. However, these studies are susceptible to publication bias and limited by methodological idiosyncrasies. To minimize these shortcomings, investigators conducted a participant-level meta-analysis of 13 published and unpublished European studies including 197,473 individuals (mean age, 42; 49% women). The same validated model was used in all of the studies to assess baseline job strain.

  • The Latest and Greatest in Anticoagulation...

    Added On : 6th October 2012

    The Latest and Greatest in Anticoagulation Still Not a Good Idea After ACS

    The newer oral anticoagulants are associated with increased rates of major bleeding that offset their antithrombotic benefit.

    The burgeoning use of new oral anticoagulants (e.g., dabigatran, rivaroxaban, apixaban) has rekindled interest in whether these agents, combined with standard antiplatelet therapy, could reduce thrombotic events after acute coronary syndromes (ACS). To synthesize the current evidence base, researchers performed a meta-analysis of seven trials in which 31,286 ACS patients were randomized to placebo or a new oral anticoagulant, either an anti-Xa or direct thrombin inhibitor. All patients also received antiplatelet therapy, and most received dual antiplatelet therapy with aspirin and a thienopyridine.

  • Reducing Co-pays for Cardiovascular Meds...

    Added On : 19th October 2012

    Reducing Co-pays for Cardiovascular Meds: More Bang for the Buck?

    Cutting co-payments for statins and clopidogrel was associated with improvements in adherence and resource utilization but no change in overall spending.

    In a recent randomized trial, provision of evidence-based drug therapy after myocardial infarction at no cost to the patients, while failing to show benefit with regard to the primary composite endpoint, was associated with improvement in both adherence and vascular events (JW Cardiol Nov 14 2011). Now, the same research group has studied the effects of reducing co-payments for statins and clopidogrel on adherence, resource utilization, and events in 2830 employees of a large company as compared with 49,801 employees of companies that did not change their co-payment policies. Pharmacy and medical services claims data from 1 year before through 1 year after the change in co-payment policy were included in the analysis.

  • Do Patients' Stroke and Bleeding Risks...

    Added On : 1st November 2012

    Do Patients' Stroke and Bleeding Risks Affect Apixaban's Advantage over Warfarin?

    In an ARISTOTLE subanalysis, apixaban maintained its edge across the range of risk scores in patients with atrial fibrillation, but stronger confirmation is needed.

    In the manufacturer-sponsored ARISTOTLE trial, apixaban outperformed warfarin for prevention of stroke or systemic embolism in 18,201 patients with atrial fibrillation (JW Cardiol Aug 29 2011). In a secondary analysis of the ARISTOTLE data, investigators have analyzed whether the results differed according to patients' scores on CHADS2 (available online), CHA2DS2VASc (available online), and HAS-BLED (available online), models commonly used to predict risks for stroke and bleeding.

  • Serelaxin: A New Gun in the HF Arsenal?

    Added On : 14th November 2012

    Results of the RELAX-AHF trial are grounds for cautious optimism.

    Persistently high hospitalization rates for acute heart failure (HF) have not given rise to effective new treatment strategies although certainly not for lack of effort (JW Cardiol Jul 6 2011, Nov 14 2007, and Apr 4 2007). Serelaxin, a recombinant vasoactive peptide, was recently the subject of an intriguing phase II study (JW Cardiol Apr 1 2009). Now, the RELAX-AHF investigators present results of a manufacturer-sponsored, double-blinded study in 1161 patients with acute HF (mean age, 72; 55% with at least moderate left ventricular systolic dysfunction). All participants had dyspnea, radiographic pulmonary edema, elevated N-terminal-proB-type natriuretic peptide levels, and mild or moderate renal dysfunction. Exclusion criteria included systolic blood pressure 125 mm Hg, intravenous HF medications (aside from diuretics or nitrates), mechanical support, and recent acute coronary syndrome. Patients were randomized to continuous infusion of serelaxin (30 g/kg/day) or placebo for 48 hours.