Although IVIg is labeled pregnancy Category C, it is likely an excellent choice of therapy.

Pemphigus often affects women of child-bearing age. Treatment usually involves the use of powerful immunosuppressive drugs and high doses of systemic corticosteroids, such as prednisone. When a patient with pemphigus becomes pregnant or develops pemphigus during pregnancy, treatment becomes even more complicated. Intravenous immunoglobulin (IVIg) is an apparently good treatment option.

Marginal Return: Safe and Sufficient Margins for Thick Melanoma

A 2-cm resection margin is sufficient for melanomas thicker than 2 mm.

Does Anti–Tumor Necrosis Factor ? Therapy Increase the Risk for Serious Infection?

In this large cohort study, unlike in most of the previous studies, researchers found no increased risk for serious infections with TNF antagonists.

Researchers identified a variant that confers susceptibility to BCCs and other cancers.

Dermatopathology Workforce in the U.S.: An Overview

Who practices dermatopathology, how happy are they, and how can we assure a continuing presence at sufficiency in academia?

To characterize the dermatopathology workforce in the U.S., these authors sent a questionnaire to all 913 Fellow members of the American Society of Dermatopathology (ASDP). The objectives were to collect data about current practice and future plans, identify characteristics of academic practitioners, and explore satisfaction regarding fellowship training.

Dr. Joel Gelfand elucidates the concept of number needed to screen in "Behind the Numbers", a new Journal Watch Dermatology feature aimed at clarifying issues in epidemiologic design and biostatistics.

Granulomatous Processes and Clonality: PCR Evaluation of T-Cell Rearrangement for Diagnosis

Analysis of T-cell clonality is useful for differentiating sarcoidosis and primary granuloma annulare from granulomatous CTCLs.

Stem Cells on the Clock: Circadian Rhythm Proteins Regulate Epidermal Stem Cells

Investigators found an association between expression of genes associated with stem cell function and expression of circadian rhythm genes.

Basal Cell Carcinoma at a Young Age: Another Consequence of Tanning Beds

Tanning bed users younger than 40 developed early-onset BCCs significantly more often than nonusers.

What Is the Optimal Frequency of Postmelanoma Follow-Up?

A new schedule would reduce the number of follow-up visits.