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  • Newly Identified Psoriasis Susceptibility Loci

    Added On : 7th January 2013

    Disruptions of both innate and acquired immune regulation can influence the development of psoriasis.

    Psoriasis is well known to have a critically important immune component. Many genome-wide association studies (GWAS) of psoriasis have identified genes involved in epidermal development and immune regulation. Tsoi and colleagues performed a meta-analysis of three GWAS and two independent data sets of genotyped individuals, with a focus on areas of the genome known to be important for immune function.

  • The Effect of Milk Intake on Vitamin D and Iron Levels...

    Added On : 20th January 2013

    The Effect of Milk Intake on Vitamin D and Iron Levels in Children

    Consuming 2 cups of milk per day is sufficient to maintain healthy vitamin D levels without depleting iron levels for most children at northern latitudes.

  • Wireless Monitoring of Pulmonary Artery...

    Added On : 13th March 2011

    Wireless Monitoring of Pulmonary Artery Pressure in Patients with Heart Failure

    An implantable sensor reduced the rate of hospitalization for HF, but the difference in out-of-hospital time was slight.

  • Low-Gradient Severe Aortic Stenosis...

    Added On : 27th March 2011

    Low-Gradient Severe Aortic Stenosis with Preserved Left Ventricular Function: A New Disease?

    An analysis of prospective data helps to elucidate the characteristics and course of a common, clinically distinct form of AS.

  • Radial or Femoral Access for Coronary Interventions?

    Added On : 10th April 2011

    In a randomized trial, a radial approach by experienced operators was similar in efficacy to a femoral approach and resulted in a lower rate of vascular complications.

    Findings from small trials and observational studies suggest that rates of vascular and bleeding complications of percutaneous coronary intervention (PCI) are lower with radial than with femoral arterial access. In a randomized, unblinded trial at 158 hospitals in 32 countries, investigators assigned 7021 patients (mean age, 62; 14% aged >75) with acute coronary syndromes (28% ST-segment-elevation myocardial infarction [STEMI]) to either radial or femoral access for coronary angiography and planned PCI between 2006 and 2010.

  • Evidence-Based Therapies for ST-Segment-Elevation...

    Added On : 8th May 2011

    Evidence-Based Therapies for ST-Segment-Elevation Myocardial Infarction Improve Survival

    A national registry in Sweden captures comprehensive data on the evolution of STEMI treatment and outcomes.

    Several reports have described trends in therapy and outcomes in patients with myocardial infarction (MI), but few have included unrestricted populations. This study focuses on trends in evidence-based therapies and mortality in 61,238 patients who had a first-time diagnosis of ST-segment-elevation MI (STEMI) at acute cardiac care hospitals throughout Sweden from 1996 through 2007.

  • Erythropoietin Does Not Reduce Infarct...

    Added On : 22nd May 2011

    Erythropoietin Does Not Reduce Infarct Size in ST-Segment-Elevation Myocardial Infarction

    In REVEAL, not only was epoetin alfa of no benefit, a suggestion of harm was seen in patients older than 70.

  • Myocardial Injury Associated with Transcatheter...

    Added On : 5th June 2011

    Myocardial Injury Associated with Transcatheter Aortic Valve Implantation

    Most patients have elevated cardiac enzyme markers after uncomplicated TAVI, but higher levels may be associated with worse outcomes.

    Little is known about adverse myocardial effects of transcatheter aortic valve implantation (TAVI), which may arise from hypotension (due to balloon valvuloplasty or rapid pacing), tissue compression during deployment, or ventricular puncture during transapical access. In this single-center Canadian study, investigators measured cardiac enzymes at multiple time points up to 72 hours after TAVI of a balloon-expandable prosthesis in 101 patients, 63 of whom had transapical access. Patients who died within 24 hours or had life-threatening procedural complications were excluded from the analysis.

  • Cardiac Rehabilitation After Percutaneous Coronary...

    Added On : 19th June 2011

    Cardiac Rehabilitation After Percutaneous Coronary Intervention Reduces Mortality

    So why are fewer than half of PCI recipients being referred?

  • Okay to Switch from Heparin to Bivalirudin...

    Added On : 3rd July 2011

    Okay to Switch from Heparin to Bivalirudin Before Primary Percutaneous Coronary Intervention

    In patients taking unfractionated heparin at baseline, those who switched did as well as — or better than — those who remained on UFH with an added glycoprotein IIb/IIIa inhibitor.

    In the industry-sponsored HORIZONS-AMI trial, investigators compared bivalirudin with unfractionated heparin (UFH) plus glycoprotein IIb/IIIa inhibition for antithrombosis during primary percutaneous coronary intervention (PCI; JW Cardiol May 21 2008). In this subanalysis, the effects of switching agents were assessed in the 2357 patients who had received UFH before randomization. Most (82%) received bolus-only UFH (about 5000 IU, on average) about 1 hour before study drug administration.

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