Half the Benefit of Sleeping Pills is Due to Powerful Placebo Effect
Half of the benefit of taking sleeping pills comes from the placebo effect, according to a major new study.
Researchers re-analysed results from more than a dozen clinical trials of the most common type of sleeping tablets, known as Z-drugs.
These drugs are frequently used in the UK and USA as a short-term treatment for insomnia with almost £25m worth of prescriptions handed out in Britain each year.
However, some health experts have questioned whether the benefits of Z-drugs (non-benzodiazepine hypnotics) justify their side effects, which can include memory loss, fatigue and impaired balance.
Questions have also been raised about the validity of published research into the effects of these drugs based on trials sponsored by pharmaceutical companies.
So academics from the University of Lincoln, Harvard Medical School and University of Connecticut conducted a meta-analysis of data from clinical trials of Z-drugs comparing drug effects with placebo effects.
They used data submitted by pharmaceutical companies to the US Food and Drug Administration (FDA) for approval of new products. This included 13 clinical trials containing 65 different comparisons and more than 4,300 participants.
Their findings, published in this week's British Medical Journal, indicate that once the placebo effect is discounted, the drug effect is of 'questionable clinical importance'.
Lead author Professor Niroshan Siriwardena, from the University of Lincoln, said: 'Our analysis showed that Z-drugs did reduce the length of time it took for subjects to fall asleep, both subjectively and as measured in a sleep lab, but around half of the effect of the drug was a placebo response.
'There was not enough evidence from the trials to show other benefits that might be important to people with sleep problems, such as sleep quality or daytime functioning.
'We know from other studies that around a fifth of people experience side effects from sleeping tablets and one in one hundred older people will have a fall, fracture or road traffic accident after using them.
'Psychological treatments for insomnia can work as effectively as sleeping tablets in the short-term and better in the long-term, so we should pay more attention to increasing access to these treatments for patients who might benefit.'
He said future studies of sleeping tablets should investigate a broader range of outcomes, not just time taken to fall asleep, and that pharmaceutical companies should be more transparent in disclosing results from their studies so that researchers can independently analyse their results.
It's thought that a third of people in the UK suffer from bouts of insomnia. It is most common in older women.
It can be caused by many different things, including stressful events, psychiatric problems, underlying physical conditions, and drug and substance misuse.
Claire Bates - MailOnline
